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Articles and Studies

Vitamin D Supplementation

We sought to examine the impact of ergocalciferol (ERGO) on recombinant human erythropoietin (EPO) use in a cohort of 25-OH vitamin D (25-D)–deficient hemodialysis (HD) patients.

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Uptake and Protective Effects of Ergothioneine in Human Endothelial Cells

Ergothioneine is a thiourea derivative of histidine found in food, especially mushrooms. Experiments in cell-free systems and chemical assays identified this compound as a powerful antioxidant. Experiments were designed to test the ability of endothelial cells to take up ergothioneine and hence benefit from protection against oxidative stress.

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L-ergothioneine poised for breakthrough in 2017

The coming year could be a big one for l-ergothioneine, an ingredient for which the scientific backing has been slowly building. New regulatory approvals and new developments in the supply sphere all augur well for this powerful antioxidant.

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Mediated Ergothioneine Uptake in Mouse Neural Progenitor Cells

The aim of the present study is to clarify the functional expression and physiological role in neural progenitor cells (NPCs) of carnitine/organic cation transporter OCTN1/SLC22A4, which accepts the naturally occurring food-derived antioxidant ergothioneine (ERGO) as a substrate in vivo.

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Ergothioneine and UV

Many changes related to aging at the cellular level may be due to the physiological condition of mitochondria. The present study was aimed at evaluating the effect of the antioxidant L-ergothioneine on UV-induced damage in skin cells. In view of our results, L-ergothioneine could be an effective skin care and anti-photoaging ingredient.

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Ergo Dietary Article

Overhydrated hereditary stomatocytosis, clinically characterized by hemolytic anemia, is a rare disorder of the erythrocyte membrane permeability to monovalent cations, associated with mutations in the Rh-associated glycoprotein gene. We assessed the red blood cell metabolome of 4 patients with this disorder and showed recurrent metabolic abnormalities associated with this disease but not due to the diminished half-life of their erythrocytes.

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Canada Vitamin D Economic Impact

The objective of this work is to estimate the economic burden and premature death rate in Canada attributable to low serum 25-hydroxyvitamin D (25(OH)D) levels. Vitamin D deficiency has been linked to many diseases and conditions in addition to bone diseases, including many types of cancer, several bacterial and viral infections, autoimmune diseases, cardiovascular diseases, and adverse pregnancy outcomes.

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Vitamin D2 vs. Vitamin D3

The authors reviewed several studies that had previously reported that vitamin D2 was as biologically effective as vitamin D3 in both pregnant women and in healthy adults. This study confirms these observations and adds to the body of scientific literature.

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L-ergothioneine is a physiologic cytoprotectant

Ergothioneine (ET) is an unusual sulfur-containing derivative of the amino acid, histidine, which is derived exclusively through the diet. Recently, a highly specific transporter for ET (ETT) was identified in mammalian tissues, which explains abundant tissue levels of ET and implies a physiologic role.

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